READABLE
The most direct way to get Letter from Doctor Simeon is through Unquenchable Thirst.
Quest or activity
Follow the linked quest. The source confirms acquisition during the quest, but does not identify a specific objective or say it is awarded when the whole quest ends.
Follow the mapped pickup or quest source first; it is the most predictable route currently listed.
The most direct way to get Letter from Doctor Simeon is through Unquenchable Thirst.
QUICK ANSWER
Readable / lore item
ITEM DECISION GUIDE
Use verified relationships and acquisition evidence before selling. A listed sell value by itself never proves that an item is disposable.
WHAT IS IT USED FOR?
Follow the quest, recipe, skill or other relation below before deciding what to do with it.
Check verified uses →CAN I SAFELY SELL IT?
The item has a confirmed non-sale relationship. Resolve that use before treating its sell value as a recommendation.
CAN I GET ANOTHER?
Use the confirmed quest, shop, crafting or fixed-world route rather than an uncertain loot pool.
REFERENCE ITEM
Signed by Doctor Simeon.